Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916793 | 0.86 | METAP2 (0.57) | MAPTTSHRTDP1NPC1RAB9A | |
| SCHEMBL10744989 | 0.81 | KAT2A (0.47) | TSHRTDP1NPC1RAB9ASLC11A2 | |
| SCHEMBL10746112 | 0.81 | NPC1 (0.43) | MAPTTSHRNPC1RAB9ASLC11A2 | |
| SCHEMBL10745118 | 0.77 | RAB9A (0.53) | MAPTTSHRTDP1NPC1RAB9A | |
| SCHEMBL10748167 | 0.75 | ALDH1A1 (0.51) | MAPTTSHRTDP1NPC1RAB9A | |
| SCHEMBL5916945 | 0.74 | MAPT (0.53) | MAPTTSHRTDP1NPC1RAB9A | |
| SCHEMBL10501336 | 0.73 | METAP2 (0.50) | MAPTTDP1PKMMEN1KMT2A | |
| SCHEMBL10502310 | 0.73 | METAP2 (0.52) | MAPTTDP1PKMMEN1KMT2A | |
| SCHEMBL10502111 | 0.73 | METAP2 (0.68) | MAPTTDP1PKMMEN1KMT2A | |
| SCHEMBL10500974 | 0.73 | METAP2 (0.54) | MAPTKMT2AHTTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |