Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11647465 | 0.83 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL23732252 | 0.83 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL3692361 | 0.81 | KDM4E (0.55) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL9671945 | 0.81 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL1317881 | 0.81 | KDM4E (0.55) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL23732254 | 0.81 | KDM4E (0.55) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL1157003 | 0.81 | MAPT (0.65) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL28289543 | 0.80 | KDM4E (0.54) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL30403242 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAL3MBTL1GAA | |
| SCHEMBL78402 | 0.80 | MAPT (0.55) | ALDH1A1MAPTLMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4070366-A | RING ALKYLATION OF SUBSTITUTED PYRROLES, ONE STEP | CANADIAN PATENTS & DEVELOPMENT LIMITED (US) | 1978-01-24 | — | — | US | claimed |
| CN-109320499-B | Pyrrole-3-formamide compound and preparation method and application thereof | 沈阳药科大学 | 2020-09-08 | — | — | CN | disclosed |
| US-9695166-B2 | Pyrazolopyridine pyrazolopyrimidine and related compounds | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150315198-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2015-11-05 | — | — | US | disclosed |
| CN-1422846-A | Pyrrole derivative preparation method | RES INST YANSHAN PETROCHEMICAL (CN) | 2003-06-11 | — | — | CN | disclosed |
| EP-0230110-A1 | Pharmacologically active pyrrole and pyrazole derivatives | FISONS plc (GB) | 1987-07-29 | — | — | EP | disclosed |
| US-4070366-A | RING ALKYLATION OF SUBSTITUTED PYRROLES, ONE STEP | CANADIAN PATENTS & DEVELOPMENT LIMITED (US) | 1978-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315198-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | TPMT, DPYD, XDH | ALDH1A1 416/4885MAPT 44/4885LMNA 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.