SCHEMBL10751687

SCHEMBL10751687

Cc1nn(C)c(O)c1C(=O)c1cc(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 4/20 0.35
KDM4E B2RXH2 3/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
HTT P42858 2/20 0.34
NR2F2 P24468 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NR3C1 P04150 4/20 0.33
LMNA P02545 3/20 0.32
ALDH1A1 P00352 2/20 0.32
SPR P35270 2/20 0.32
POLB P06746 1/20 0.32
ALPL P05186 1/20 0.31
GAA P10253 1/20 0.31
GALR3 O60755 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10801002 0.90 MAPT (0.34) KMT2AMEN1MAPTKDM4EL3MBTL1
SCHEMBL10808922 0.90 MAPT (0.34) KMT2AMEN1MAPTKDM4EL3MBTL1
SCHEMBL10754739 0.85 MAPT (0.38) KMT2AMEN1MAPTKDM4EL3MBTL1
SCHEMBL10803143 0.81 L3MBTL1 (0.41) KMT2AMEN1MAPTKDM4EL3MBTL1
SCHEMBL10680900 0.79 MAPT (0.36) KMT2AMEN1MAPTKDM4EL3MBTL1
SCHEMBL1324474 0.79 KMT2A (0.52) KMT2AMEN1MAPTKDM4EHTT
SCHEMBL10751550 0.79 MAPT (0.43) KMT2AMEN1MAPTKDM4EHTT
SCHEMBL10751359 0.78 ALDH1A1 (0.46) KMT2AMAPTSMN1; SMN2NR3C1LMNA
SCHEMBL10754395 0.78 KMT2A (0.51) KMT2AMEN1MAPTKDM4EHTT
SCHEMBL10752411 0.78 SMN1; SMN2 (0.51) KMT2AMEN1MAPTKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4687858-A HERBICIDES SANKYO COMPANY LIMITED (JP) 1987-08-18 US disclosed
US-4508910-A Herbicidal 4-benzoyl-5-hydroxy-pyrazales SANKYO COMPANY LTD. (JP) 1985-04-02 US disclosed
US-4414392-A Herbicidal compositions and pyrazole derivatives SANKYO COMPANY, LTD. (JP) 1983-11-08 US disclosed
US-4301293-A Herbicidal compositions and pyrazole derivatives SANKYO COMPANY LTD. (JP) 1981-11-17 US disclosed
US-4146726-A HERBICIDES SANKYO COMPANY LIMITED (JP) 1979-03-27 US disclosed
US-4063925-A Herbicidal compositions SANKYO COMPANY LIMITED (JA) 1977-12-20 US disclosed