SCHEMBL10752159

SCHEMBL10752159

Oc1cc2c(cc1C1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2

nearest known ligand 0.75

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.75
CYP3A4 P08684 2/20 0.75
TRPM8 Q7Z2W7 1/20 0.75
CYP2D6 P10635 1/20 0.75
CYP2C9 P11712 1/20 0.75
CYP2C19 P33261 1/20 0.75
HPGD P15428 1/20 0.75
MAPK1 P28482 1/20 0.75
SMN1; SMN2 Q16637 1/20 0.75
MCL1 Q07820 1/20 0.75
PPARG P37231 4/20 0.67
PPARD Q03181 4/20 0.67
PPARA Q07869 1/20 0.67
PTPN1 P18031 2/20 0.53
ALOX5 P09917 2/20 0.53
ALOX15B O15296 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
MAPK9 P45984 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2783534 1.00 MAPT (0.75) MAPTCYP3A4TRPM8CYP2D6CYP2C9
SCHEMBL12600772 1.00 MAPT (0.75) MAPTCYP3A4TRPM8CYP2D6CYP2C9
SCHEMBL3497076 1.00 MAPT (0.75) MAPTCYP3A4TRPM8CYP2D6CYP2C9
SCHEMBL29540188 1.00 MAPT (0.75) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Sesamin SCHEMBL23045677 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Asarinin SCHEMBL19313765 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Asarinin SCHEMBL3498030 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Asarinin SCHEMBL6704290 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Asarinin SCHEMBL29540276 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9
Asarinin SCHEMBL30384235 0.87 MAPT (1.00) MAPTCYP3A4TRPM8CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9629823-B2 Composition for promoting collagen production, for promoting elastin production and/or for promoting keratinocyte migration and usage therefor PUBLIC UNIVERSITY CORPORATION OSAKA CITY UNIVERSITY (JP) 2017-04-25 US disclosed
US-9629823-B2 Composition for promoting collagen production, for promoting elastin production and/or for promoting keratinocyte migration and usage therefor PUBLIC UNIVERSITY CORPORATION OSAKA CITY UNIVERSITY (JP) 2017-04-25 US disclosed
US-20160175280-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION, FOR PROMOTING ELASTIN PRODUCTION AND/OR FOR PROMOTING KERATINOCYTE MIGRATION AND USAGE THEREFOR KIYOMOTO IRON & MACHINERY WORKS CO LTD (JP) 2016-06-23 US disclosed
US-20160175280-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION, FOR PROMOTING ELASTIN PRODUCTION AND/OR FOR PROMOTING KERATINOCYTE MIGRATION AND USAGE THEREFOR KIYOMOTO IRON & MACHINERY WORKS CO LTD (JP) 2016-06-23 US disclosed
US-20160143877-A1 COMPOSITION FOR SUPPRESSING ADIPOCYTE DIFFERENTIATION, FOR REDUCING FAT ACCUMULATION AND/OR FOR PROMOTING ADIPONECTIN SECRETION AND USAGE FOR SAID COMPOSITION KIYOMOTO IRON & MACHINERY WORKS CO LTD (JP) 2016-05-26 US disclosed
US-20160143877-A1 COMPOSITION FOR SUPPRESSING ADIPOCYTE DIFFERENTIATION, FOR REDUCING FAT ACCUMULATION AND/OR FOR PROMOTING ADIPONECTIN SECRETION AND USAGE FOR SAID COMPOSITION KIYOMOTO IRON & MACHINERY WORKS CO LTD (JP) 2016-05-26 US disclosed
US-4708820-A ACID CATALYST TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) 1987-11-24 US disclosed
US-4649206-A ANTIOXIDANT FROM SESAME SEEDS TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) 1987-03-10 US disclosed
EP-0207735-A1 Method of manufacturing phenol-type natural antioxidants Takemoto Yushi Kabushiki Kaisha (JP) 1987-01-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160175280-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION, FOR PROMOTING ELASTIN PRODUCTION AND/OR FOR PROMOTING KERATINOCYTE MIGRATION AND USAGE THEREFOR COL14A1, COL1A1, COL2A1 MAPT 3490/4885CYP3A4 4481/4885TRPM8 4357/4885
US-20160143877-A1 COMPOSITION FOR SUPPRESSING ADIPOCYTE DIFFERENTIATION, FOR REDUCING FAT ACCUMULATION AND/OR FOR PROMOTING ADIPONECTIN SECRETION AND USAGE FOR SAID COMPOSITION FABP4, ADIPOR1, ADIPOR2 MAPT 4671/4885CYP3A4 4731/4885TRPM8 4713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.