Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747959 | 0.82 | ENPP2 (0.42) | — | |
| SCHEMBL10753390 | 0.81 | CA2 (0.53) | — | |
| SCHEMBL10754745 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL17290281 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL10754928 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2MAPTALDH1A1HTTOPRD1 | |
| SCHEMBL65856 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL5249012 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTALDH1A1LMNAHTT | |
| SCHEMBL10756141 | 0.73 | ALDH1A1 (0.44) | MAPTALDH1A1HTT | |
| SCHEMBL27520267 | 0.73 | CA1 (0.53) | MAPTALDH1A1GAATSHRL3MBTL1 | |
| SCHEMBL10752669 | 0.73 | PARP10 (0.52) | SMN1; SMN2MAPTALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716169-A | INOTROPIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-12-29 | — | — | US | disclosed |
| EP-0185345-A1 | Imidazo derivatives, their preparation and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |
| EP-0185346-A2 | Imidazo derivatives, their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |