Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10753482 | 1.00 | TSHR (0.44) | TSHRCYP3A4KMT2AMEN1MAPT | |
| SCHEMBL10754642 | 0.84 | ALDH1A1 (0.47) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL10754644 | 0.84 | ALDH1A1 (0.47) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL9693341 | 0.80 | HPGD (0.52) | CYP3A4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL9693336 | 0.80 | HPGD (0.52) | CYP3A4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10762108 | 0.76 | KMT2A (0.44) | TSHRCYP3A4KMT2AMEN1MAPT | |
| SCHEMBL10762105 | 0.76 | KMT2A (0.44) | TSHRCYP3A4KMT2AMEN1MAPT | |
| SCHEMBL10657656 | 0.74 | PDE3B (0.42) | CYP3A4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10757707 | 0.74 | KMT2A (0.44) | TSHRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10757702 | 0.74 | KMT2A (0.44) | TSHRKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |