Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.42 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.42 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10754642 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10753480 | 0.84 | TSHR (0.44) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10753482 | 0.84 | TSHR (0.44) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10657656 | 0.78 | PDE3B (0.42) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10657645 | 0.78 | PDE3B (0.42) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10758207 | 0.78 | POLB (0.66) | ALDH1A1MAPTKDM4EHPGDGAA | |
| SCHEMBL10758203 | 0.78 | POLB (0.66) | ALDH1A1MAPTKDM4EHPGDGAA | |
| SCHEMBL10657105 | 0.77 | FFAR1 (0.43) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10658718 | 0.77 | PDE3B (0.46) | ALDH1A1MAPTKDM4EHPGDPLIN1 | |
| SCHEMBL10658721 | 0.77 | PDE3B (0.46) | ALDH1A1MAPTKDM4EHPGDPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |