Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16765597 | 0.86 | KMT2A (0.52) | LMNAALDH1A1TSHRSLC6A3KMT2A | |
| SCHEMBL27375218 | 0.85 | SLC6A3 (0.68) | CYP3A4ALDH1A1HSD17B10TSHRSLC6A3 | |
| SCHEMBL8442291 | 0.83 | LMNA (0.50) | LMNACYP1A2CYP3A4MAOAALDH1A1 | |
| SCHEMBL10334181 | 0.83 | LMNA (0.50) | LMNACYP1A2CYP3A4MAOAALDH1A1 | |
| SCHEMBL5706020 | 0.83 | SLC6A3 (0.69) | LMNACYP1A2ALDH1A1HSD17B10TSHR | |
| SCHEMBL5058312 | 0.83 | ESR2 (0.56) | LMNACYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL2750155 | 0.82 | ALDH1A1 (0.51) | LMNACYP1A2CYP3A4MAOAALDH1A1 | |
| SCHEMBL1671606 | 0.80 | LMNA (0.53) | LMNACYP1A2CYP3A4MAOAALDH1A1 | |
| SCHEMBL2691568 | 0.80 | MAPT (0.51) | LMNACYP1A2CYP3A4HSD17B10TSHR | |
| SCHEMBL6588826 | 0.80 | LMNA (0.53) | LMNACYP1A2CYP3A4MAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4650868-A | 7-deazapurine derivatives useful as antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0160910-A2 | 7-Deazapurine derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1985-11-13 | — | — | EP | disclosed |