Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.60 |
| ▸ | PTGER4 | P35408 | 7/20 | 0.60 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.60 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990040 | 0.83 | PTGER1 (0.60) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL2038509 | 0.82 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL17197391 | 0.80 | HTR1A (0.79) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8676328 | 0.80 | PTGER1 (0.59) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL10753679 | 0.79 | FFAR1 (0.68) | TDP1 | |
| SCHEMBL7425846 | 0.77 | MEN1 (0.60) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL31561714 | 0.77 | HTR1A (0.69) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL3159332 | 0.77 | HTR1A (0.69) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL3930253 | 0.77 | HTR1A (0.59) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8675205 | 0.77 | PTGER1 (0.71) | PTGER1PTGER4PTGER3PTGER2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |