SCHEMBL7990040

SCHEMBL7990040

COC(=O)CCCc1ccccc1OCc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 3/20 0.60
PTGER4 P35408 3/20 0.60
PTGER3 P43115 3/20 0.60
PTGER2 P43116 3/20 0.60
HTR1A P08908 2/20 0.56
DRD2 P14416 2/20 0.56
ABCB1 P08183 6/20 0.53
MGLL Q99685 1/20 0.53
MTNR1A P48039 3/20 0.51
MTNR1B P49286 2/20 0.51
HPGD P15428 1/20 0.49
GAA P10253 1/20 0.49
BRD4 O60885 1/20 0.49
ABCG2 Q9UNQ0 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3930253 0.92 HTR1A (0.59) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL2985026 0.87 LMNA (0.51) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL8676328 0.85 PTGER1 (0.59) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL8320582 0.84 PTGER4 (0.69) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL28569135 0.84 PPARD (0.53) GAA
SCHEMBL10758591 0.83 PTGER1 (0.60) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL31757763 0.82 L3MBTL1 (0.56) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL2988197 0.82 L3MBTL1 (0.56) PTGER1PTGER4PTGER3PTGER2HTR1A
SCHEMBL28122148 0.82 MTNR1A (0.58) MTNR1AMTNR1BHPGD
SCHEMBL31155910 0.82 PPARD (0.54) HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288105-B1 COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE ELI LILLY AND COMPANY 2001-09-11 US disclosed
US-6207686-B1 FOR THERAPY OF HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
WO-1996015109-A1 ENDOTHELIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-23 WO disclosed
US-4761420-A CARDIOVASCULAR DISORDERS LABORATOIRES SYNTEX S.A. (FR) 1988-08-02 US disclosed
EP-0249245-A2 Antihypertensive dihydropyridine derivatives LABORATOIRES SYNTEX S.A. (FR) 1987-12-16 EP disclosed