Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494425 | 0.79 | SLC6A3 (0.37) | OPRM1OPRL1ICMTOPRD1OPRK1 | |
| SCHEMBL11494764 | 0.78 | SLC6A3 (0.36) | OPRM1OPRL1ICMTOPRD1OPRK1 | |
| SCHEMBL4277931 | 0.78 | THRB (0.39) | ALDH1A1TP53HTTMEN1KMT2A | |
| SCHEMBL1256099 | 0.77 | CHEK2 (0.39) | OPRM1OPRL1ALDH1A1OPRK1SIGMAR1 | |
| SCHEMBL11699538 | 0.77 | KCNH2 (0.39) | OPRM1OPRL1ICMTSLC6A2SLC6A3 | |
| SCHEMBL6754026 | 0.77 | OPRM1 (0.33) | OPRM1OPRL1ICMTTP53SLC6A2 | |
| SCHEMBL11283171 | 0.76 | OPRM1 (0.49) | OPRM1OPRL1ALDH1A1ICMTOPRD1 | |
| SCHEMBL27825774 | 0.75 | CHEK2 (0.38) | OPRM1OPRL1ALDH1A1OPRK1SIGMAR1 | |
| SCHEMBL6755371 | 0.73 | ALDH1A1 (0.33) | OPRM1OPRL1ALDH1A1ICMTTP53 | |
| SCHEMBL754463 | 0.72 | SLC6A3 (0.41) | OPRM1OPRL1ICMTSLC6A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695634-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1987-09-22 | — | — | US | disclosed |
| US-4622406-A | CHEMICAL INTERMEDIATES, TRIMETHYLSILOXY COMPOUNDS | PFIZER INC. (US) | 1986-11-11 | — | — | US | disclosed |
| US-4562267-A | Intermediates of hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1985-12-31 | — | — | US | disclosed |
| US-4454320-A | Process for 5-substituted dialuric acids | PFIZER INC. (US) | 1984-06-12 | — | — | US | disclosed |
| US-4423233-A | ALPHA-HYDROXY CARBOXIMIDATE INTERMEDIATES | PFIZER INC. (US) | 1983-12-27 | — | — | US | disclosed |
| US-4381308-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-04-26 | — | — | US | disclosed |
| US-4332952-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1982-06-01 | — | — | US | disclosed |