Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106421 | 0.82 | CTSA (0.47) | CTSACNR2BRD4P2RX7GAA | |
| SCHEMBL106400 | 0.73 | PSMB8 (0.40) | CNR2NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31514785 | 0.72 | CTSA (0.54) | CTSAGRM4CNR1CLK1CLK2 | |
| SCHEMBL108486 | 0.71 | NPC1 (0.49) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL29403395 | 0.71 | KMT2A (0.44) | ALDH1A1 | |
| SCHEMBL29396394 | 0.70 | BRD4 (0.54) | CTSAGRM4BRD4P2RX7CLK1 | |
| SCHEMBL19898227 | 0.70 | BRD4 (0.54) | CTSAGRM4BRD4P2RX7CLK1 | |
| SCHEMBL108143 | 0.70 | P2RX7 (0.62) | CTSAGRM4P2RX7ALDH1A1GAA | |
| SCHEMBL109203 | 0.69 | SIRT6 (0.41) | CNR2NPC1ALDH1A1LMNAMAPT | |
| SCHEMBL15743805 | 0.69 | CTSA (0.51) | CTSACNR2GRM4P2RX7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |