Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17883351 | 0.73 | RAB9A (0.55) | PSMB8ACACBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL107632 | 0.73 | CTSA (0.46) | CNR2ALDH1A1L3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL109203 | 0.71 | SIRT6 (0.41) | CNR2ALDH1A1L3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL106421 | 0.71 | CTSA (0.47) | CNR2 | |
| SCHEMBL26269687 | 0.69 | PSMB8 (0.39) | PSMB8ACACBCNR2RAPGEF3RAPGEF4 | |
| SCHEMBL4002227 | 0.69 | ROCK1 (0.51) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL24567552 | 0.68 | ACACB (0.46) | PSMB8ACACBRAPGEF3RAPGEF4SGPL1 | |
| SCHEMBL157610 | 0.68 | — | — | |
| SCHEMBL109899 | 0.68 | SMYD3 (0.40) | ALDH1A1SMN1; SMN2NPC1HTTRAB9A | |
| SCHEMBL656888 | 0.67 | ATM (0.43) | ACACBALDH1A1CHRNA4SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |