SCHEMBL10769830

SCHEMBL10769830

CC(C)(C)c1ccc(CCOc2cnn(C(C)(C)C)c(=O)c2Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.61
MEN1 O00255 2/20 0.61
NPC1 O15118 2/20 0.61
RAB9A P51151 2/20 0.61
GALR3 O60755 1/20 0.61
NR2F2 P24468 1/20 0.61
GPR183 P32249 1/20 0.61
GPR35 Q9HC97 1/20 0.61
SMN1; SMN2 Q16637 6/20 0.46
LMNA P02545 2/20 0.46
HPGD P15428 2/20 0.45
HTT P42858 2/20 0.45
ATM Q13315 1/20 0.45
NPSR1 Q6W5P4 1/20 0.42
MAPK1 P28482 3/20 0.39
MAPK14 Q16539 1/20 0.39
GAA P10253 1/20 0.37
ALDH1A1 P00352 2/20 0.37
ABCC8 Q09428 1/20 0.36
KCNJ11 Q14654 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9232300 0.88 RAB9A (0.63) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL10670074 0.83 SMN1; SMN2 (0.47) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL18672266 0.81 SMN1; SMN2 (0.53) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL10366104 0.79 SMN1; SMN2 (0.51) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL15565322 0.79 SMN1; SMN2 (0.43) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL9283194 0.79 NPC1 (0.52) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL15566568 0.79 RAB9A (0.52) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL21442571 0.79 SMN1; SMN2 (0.46) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL18672268 0.79 SMN1; SMN2 (0.46) KMT2AMEN1NPC1RAB9AGALR3
SCHEMBL18431065 0.79 NPC1 (0.52) KMT2AMEN1NPC1RAB9AGALR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0232825-A2 Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1987-08-19 EP disclosed