Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.37 |
| ▸ | ME1 | P48163 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171801 | 0.73 | MAPT (0.54) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9428983 | 0.71 | L3MBTL1 (0.51) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL5020109 | 0.71 | MEN1 (0.49) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10733538 | 0.67 | KDM4E (0.55) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10730382 | 0.67 | KDM4E (0.55) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10636998 | 0.65 | SNCA (0.49) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8970941 | 0.63 | GAA (0.40) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7430660 | 0.62 | MEN1 (0.52) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL14709398 | 0.62 | GAA (1.00) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| Phenothiazine SCHEMBL6899934 | 0.61 | NOX1 (0.69) | GAAMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239050-A1 | 2,3-Dihydro-2-phenyl-5-aminoalkyl-naphto ¬1,8-bc -1,5-thiazocin-4 (5H)-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-30 | — | — | EP | claimed |