Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10771614 | 0.79 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10562288 | 0.73 | SLC6A2 (0.51) | SIGMAR1GSK3AGSK3BSLC6A4NPC1 | |
| SCHEMBL10832722 | 0.70 | SIGMAR1 (0.44) | SIGMAR1GSK3AGSK3BPOLB | |
| SCHEMBL1491103 | 0.68 | ALDH1A1 (0.49) | SIGMAR1GSK3AGSK3BPOLBMAOA | |
| SCHEMBL10719904 | 0.67 | SIGMAR1 (0.44) | SIGMAR1GSK3AGSK3BPOLBLTA4H | |
| SCHEMBL18462236 | 0.66 | DAO (0.48) | SIGMAR1GSK3AGSK3BPOLB | |
| SCHEMBL28353517 | 0.64 | HTR2A (0.64) | SIGMAR1SMN1; SMN2MAOA | |
| SCHEMBL15347959 | 0.64 | HTR2A (0.71) | SIGMAR1SMN1; SMN2MAOA | |
| SCHEMBL451456 | 0.63 | MAOA (0.74) | SIGMAR1MAOA | |
| SCHEMBL54347 | 0.63 | HTR2A (0.70) | SIGMAR1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0246888-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |