Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10784558 | 0.88 | PDK2 (0.48) | IDH1PPARGPPARAPPARDMAPT | |
| SCHEMBL10784895 | 0.86 | MAPT (0.48) | IDH1GAANPSR1PPARGPPARA | |
| SCHEMBL10356364 | 0.85 | TRPM8 (0.55) | MAPTNPC1RAB9AMAOBKDM4E | |
| SCHEMBL10790253 | 0.83 | THRB (0.46) | NPSR1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL9811728 | 0.82 | KDM4E (0.60) | IDH1GAAPPARGPPARAMAPT | |
| SCHEMBL5279675 | 0.82 | GAA (0.60) | IDH1GAANPSR1PPARDMAPT | |
| SCHEMBL23605965 | 0.79 | GAA (0.56) | IDH1GAANPSR1PPARDMAPT | |
| SCHEMBL10813312 | 0.78 | FAAH (0.45) | GAAPPARGPPARAPPARDMAPT | |
| SCHEMBL10783493 | 0.77 | NR4A2 (0.55) | MAPTPOLBMAOBNR4A2 | |
| SCHEMBL10799129 | 0.77 | FAAH (0.44) | GAAPPARGPPARAPPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116787-B1 | 1,1-DIPHENYLPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-03-18 | — | — | EP | claimed |
| EP-0116787-A1 | 1,1-Diphenylpropanol derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-08-29 | — | — | EP | claimed |
| EP-0116787-B1 | 1,1-DIPHENYLPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1987-03-18 | — | — | EP | disclosed |
| US-4605785-A | I(DUCE POLYSUBSTRATE MONOOXYGENASE ENZYME SYSTEM OF LIV)R WI HOUT GENTS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-08-12 | — | — | US | disclosed |
| EP-0116787-A1 | 1,1-Diphenylpropanol derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-08-29 | — | — | EP | disclosed |