Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | APLNR | P35414 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266527 | 0.88 | NPC1 (0.58) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL490637 | 0.88 | POLB (0.71) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL9668685 | 0.88 | F2RL1 (0.53) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL585472 | 0.87 | APLNR (0.56) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL2398226 | 0.87 | POLB (0.53) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL28028759 | 0.87 | MTNR1A (0.59) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL7332981 | 0.86 | HSD17B10 (0.63) | POLBNPC1PKMRAB9AHSD17B10 | |
| SCHEMBL11576234 | 0.85 | POLB (0.51) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL7194960 | 0.85 | RAB9A (0.72) | POLBAPLNRNPC1PKMRAB9A | |
| SCHEMBL10915038 | 0.83 | MTNR1A (0.62) | POLBAPLNRNPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108484574-A | The preparation and application of tetrahydro isoquinoline derivative | 广东医科大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-104254534-A | Modulators of HEC1 activity and methods thereof | TAIVEX THERAPEUTICS CORP | 2014-12-31 | — | — | CN | disclosed |
| CN-102264716-A | Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders | — | 2011-11-30 | — | — | CN | disclosed |
| US-4647446-A | Rapid brain scanning radiopharmaceutical | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1987-03-03 | — | — | US | disclosed |