Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.74 |
| ▸ | GAA | P10253 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 7/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5448347 | 0.83 | GAA (0.64) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL4555003 | 0.79 | IDO1 (0.78) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL10789222 | 0.79 | LMNA (0.56) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL13735975 | 0.79 | LMNA (0.69) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL2236429 | 0.78 | GAA (0.66) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL28820821 | 0.77 | LMNA (0.70) | MAPTGAALMNAALDH1A1KDM4E | |
| SCHEMBL8611437 | 0.77 | GAA (0.64) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL4555049 | 0.76 | MEN1 (0.68) | MAPTGAALMNAHTTALDH1A1 | |
| SCHEMBL1647857 | 0.76 | ALDH1A1 (0.69) | MAPTGAALMNAALDH1A1MAPK1 | |
| SCHEMBL10786460 | 0.75 | LMNA (0.82) | MAPTGAALMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4713382-A | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents | SYNTEX (U.S.A.) INC. (US) | 1987-12-15 | — | — | US | disclosed |
| EP-0204265-A1 | N-Phenyl-4-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents | LABORATOIRES SYNTEX S.A. (FR) | 1986-12-10 | — | — | EP | disclosed |
| US-4199413-A | TIN SALT LAYER GIVES HIGH DENSITY IMAGES | MITA INDUSTRIAL COMPANY LIMITED (JP) | 1980-04-22 | — | — | US | disclosed |