Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555003 | 0.83 | IDO1 (0.78) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL13737508 | 0.82 | LMNA (0.63) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL10789304 | 0.82 | LMNA (0.63) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL10662740 | 0.82 | LMNA (0.67) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL10660750 | 0.80 | IDO1 (0.68) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL8979285 | 0.80 | LMNA (0.70) | LMNASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14120022 | 0.80 | MAPT (0.62) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL10786460 | 0.79 | LMNA (0.82) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL10787178 | 0.79 | MAPT (0.74) | LMNASMN1; SMN2MEN1KMT2AIDO1 | |
| SCHEMBL5463751 | 0.77 | ALDH1A1 (0.57) | LMNASMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012149093-A1 | 2-GUANIDINO-4-OXO-IMIDAZOLINE DERIVATIVES AS ANTIMALARIAL AGENTS, SYNTHESIS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY (US) | 2012-11-01 | — | — | WO | disclosed |