Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647360 | 0.87 | SMN1; SMN2 (0.59) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11563323 | 0.86 | CRHBP (0.53) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10879548 | 0.81 | KMT2A (0.58) | SMN1; SMN2HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL10792688 | 0.80 | JAK2 (0.42) | SMN1; SMN2NPC1GAARAB9AALDH1A1 | |
| SCHEMBL10877847 | 0.78 | TDP1 (0.51) | CYP2C9SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL10877660 | 0.78 | HPGD (0.58) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL10879218 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2NPC1GAAHTTMEN1 | |
| SCHEMBL12892210 | 0.76 | JAK2 (0.55) | CYP1A2CYP2C19SMN1; SMN2NPC1KMT2A | |
| SCHEMBL10791103 | 0.76 | ALPL (0.67) | SMN1; SMN2HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL12892214 | 0.76 | ALPL (0.55) | CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135032-B1 | CARBAMATES AND OXALYL AMIDES OF AMINO-N-(1H-TETRAZOL-5-YL) BENZAMIDES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-30 | — | — | EP | disclosed |
| US-4526979-A | Carbamates and oxalamides of amino-N-(1H-tetrazol-5-yl)benzamides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0135032-A1 | Carbamates and oxalyl amides of amino-N-(1H-tetrazol-5-yl) benzamides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-03-27 | — | — | EP | disclosed |