Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPOR | P19235 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 7/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825943 | 0.82 | TGM2 (0.59) | TGM2CYP1A2ITGB3ITGAV | |
| SCHEMBL9825615 | 0.81 | TGM2 (0.44) | TGM2CYP1A2ALDH1A1ITGB3ITGA2B | |
| SCHEMBL9826404 | 0.78 | TGM2 (0.44) | TGM2CYP1A2ITGB3ITGA2BMME | |
| SCHEMBL9825336 | 0.78 | TGM2 (0.69) | TGM2CYP1A2 | |
| SCHEMBL9826397 | 0.78 | TGM2 (0.69) | TGM2CYP1A2 | |
| SCHEMBL9825407 | 0.78 | TGM2 (0.42) | TGM2CYP1A2ALDH1A1HSD17B10ITGB3 | |
| SCHEMBL9825638 | 0.77 | TGM2 (0.57) | TGM2CYP1A2ITGB3ITGA2BITGAV | |
| SCHEMBL9826129 | 0.77 | CTSL (0.54) | TGM2CYP1A2LMNAITGB3ITGAV | |
| SCHEMBL9825517 | 0.77 | TGM2 (0.75) | TGM2 | |
| SCHEMBL9825735 | 0.76 | CTSL (0.56) | TGM2CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |