Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 13/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826662 | 0.90 | TGM2 (0.53) | TGM2CYP1A2CASP1ALDH1A1CYP3A4 | |
| SCHEMBL4934726 | 0.88 | TGM2 (0.44) | TGM2CYP1A2CASP1ALDH1A1CYP3A4 | |
| SCHEMBL9825126 | 0.87 | TGM2 (0.43) | TGM2CYP1A2CASP1ALDH1A1CYP3A4 | |
| SCHEMBL9826958 | 0.87 | TGM2 (0.33) | TGM2CASP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9826404 | 0.80 | TGM2 (0.44) | TGM2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9825753 | 0.78 | FNTA (0.36) | TGM2CYP1A2CASP1ALDH1A1CYP3A4 | |
| SCHEMBL10795296 | 0.78 | TGM2 (0.44) | TGM2CYP1A2ALDH1A1HSD17B10ITGB3 | |
| SCHEMBL9825735 | 0.77 | CTSL (0.56) | TGM2CYP1A2CASP1CYP3A4CYP2C9 | |
| SCHEMBL9825615 | 0.77 | TGM2 (0.44) | TGM2CYP1A2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL4598486 | 0.76 | TGM2 (0.43) | TGM2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |