Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 7/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803 | 0.93 | HTR2A (0.51) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| Hydrochloric Acid SCHEMBL1021139 | 0.91 | HTR2A (0.50) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL711807 | 0.86 | APLNR (0.50) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| Hydrochloric Acid SCHEMBL28532829 | 0.85 | APLNR (0.49) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL14501834 | 0.83 | HTR6 (0.40) | HTR6MMP8MMP13MMP1ALDH1A1 | |
| SCHEMBL777971 | 0.83 | MAPT (0.56) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL7541817 | 0.83 | HTR2A (0.56) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL336837 | 0.82 | HTR2A (0.45) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL10799767 | 0.81 | MAPT (0.45) | HTR2AKCNH2HTR2CMAPTHTR6 | |
| SCHEMBL776895 | 0.81 | MAPT (0.55) | HTR2AKCNH2HTR2CMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642348-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4593102-A | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0160436-A2 | N-[(Amino)Alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-11-06 | — | — | EP | disclosed |