Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.38 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10797930 | 0.99 | APLNR (0.40) | APLNRMETAP2CXCR2CX3CR1HTR6 | |
| SCHEMBL10795662 | 0.78 | METAP2 (0.45) | METAP2HTR6 | |
| SCHEMBL10798931 | 0.78 | APLNR (0.38) | APLNRMETAP2CXCR2 | |
| SCHEMBL10795182 | 0.78 | CXCR2 (0.43) | APLNRCXCR2CX3CR1HTR6 | |
| Hydrochloric Acid SCHEMBL10797733 | 0.77 | METAP2 (0.44) | METAP2 | |
| Hydrochloric Acid SCHEMBL10800177 | 0.77 | CXCR2 (0.42) | APLNRCXCR2CX3CR1HTR6 | |
| SCHEMBL10794598 | 0.75 | HTR6 (0.54) | APLNRHTR6 | |
| Hydrochloric Acid SCHEMBL10795401 | 0.74 | HTR6 (0.53) | APLNRHTR6 | |
| SCHEMBL10795334 | 0.74 | DRD2 (0.42) | APLNRCXCR2HTR6 | |
| SCHEMBL10795383 | 0.72 | CA12 (0.47) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642348-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4593102-A | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0160436-A2 | N-[(Amino)Alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-11-06 | — | — | EP | disclosed |