Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10799263 | 1.00 | ALDH1A1 (0.64) | ALDH1A1MAPTPKMLMNAGAA | |
| SCHEMBL88746 | 0.87 | MMP12 (0.58) | ALDH1A1MAPTLMNAGAAKMT2A | |
| Hydrochloric Acid SCHEMBL6518631 | 0.85 | MMP12 (0.56) | ALDH1A1MAPTLMNAGAAKMT2A | |
| Hydrochloric Acid SCHEMBL30293243 | 0.85 | MMP12 (0.56) | ALDH1A1MAPTLMNAGAAKMT2A | |
| SCHEMBL5308812 | 0.79 | ALDH1A1 (1.00) | ALDH1A1MAPTPKMLMNAGAA | |
| SCHEMBL26604998 | 0.77 | MMP12 (0.56) | ALDH1A1MAPTPKMLMNAGAA | |
| SCHEMBL29546895 | 0.75 | MMP12 (0.49) | ALDH1A1MAPTLMNAGAAKMT2A | |
| SCHEMBL29546109 | 0.73 | MMP12 (0.51) | ALDH1A1MAPTPKMLMNAGAA | |
| SCHEMBL29546489 | 0.73 | MMP12 (0.51) | ALDH1A1MAPTPKMLMNAGAA | |
| SCHEMBL15479700 | 0.72 | SMN1; SMN2 (0.48) | LMNAGAAKMT2APARP1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4686222-A | ADRENERGIC BLOCKERS, BRONCHODILATORS | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |