Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805772 | 0.89 | KCNK3 (0.53) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10799600 | 0.86 | HTR1A (0.53) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10803089 | 0.80 | ADORA1 (0.43) | DRD3DRD2TSHRKDM4EHSD17B10 | |
| SCHEMBL10805409 | 0.80 | HTR1A (0.54) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10805648 | 0.77 | KCNK3 (0.60) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10799991 | 0.76 | KCNK3 (0.68) | HTR1ADRD3DRD2HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL10814988 | 0.76 | KCNK3 (0.67) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10803941 | 0.74 | DRD2 (0.56) | HTR1ADRD3DRD2HTR2AHRH1 | |
| SCHEMBL10814900 | 0.73 | HTR5A (0.51) | HTR5A | |
| SCHEMBL10621004 | 0.69 | HTR1A (0.69) | HTR1ADRD3DRD2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086422-B1 | PHARMACOLOGICALLY ACTIVE PYRAZOLO(4,3-C)PYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1987-09-30 | — | — | EP | disclosed |