Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080641 | 1.00 | POLB (0.38) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL1060697 | 0.84 | POLB (0.50) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL1060694 | 0.84 | POLB (0.50) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL16054838 | 0.76 | LMNA (0.44) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL10065266 | 0.76 | CYP2D6 (0.53) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL16054840 | 0.76 | LMNA (0.44) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL16054837 | 0.76 | LMNA (0.44) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL16054834 | 0.76 | LMNA (0.44) | POLBTDP1SMN1; SMN2HTTNPC1 | |
| SCHEMBL13078096 | 0.76 | SMN1; SMN2 (0.55) | POLBSMN1; SMN2HTTNPC1GAA | |
| SCHEMBL15462268 | 0.71 | POLB (0.38) | POLBTDP1SMN1; SMN2HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451795-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | Ottawa Hospital Research Institute (CA) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011003191-A1 | COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY | OTTAWA HOSPITAL RESEARCH INSTITUTE (CA) | 2011-01-13 | — | — | WO | disclosed |