Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | MITF | O75030 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | RNF4 | P78317 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10734378 | 0.86 | ALDH1A1 (0.68) | ALDH1A1RAB9AHPGDNPC1HTT | |
| SCHEMBL44662 | 0.85 | HTT (0.78) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL2940113 | 0.83 | ALDH1A1 (0.65) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL27422908 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Methane SCHEMBL27966936 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9483678 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL27754901 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Iodide SCHEMBL998878 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL10948577 | 0.83 | HTT (0.75) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL9081388 | 0.82 | NPC1 (0.76) | ALDH1A1RAB9AHPGDNPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438167-A | Compounds having O-GlcNAc enzyme inhibitory activity and uses thereof | 美迪福伦DBT有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
| US-20200054651-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-20 | — | — | US | disclosed |
| US-20200054651-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-20 | — | — | US | disclosed |
| CN-110785426-A | Compositions and methods for modulating PPP2R1A | 加利福尼亚大学董事会 | 2020-02-11 | — | — | CN | disclosed |
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | FRONTIER MEDICINES CORPORATION | 2019-09-26 | — | — | US | disclosed |
| WO-2018144871-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018144869-A1 | COMPOSITONS AND METHODS FOR MODULATING UBA5 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018144869-A1 | COMPOSITONS AND METHODS FOR MODULATING UBA5 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018144871-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-09 | — | — | WO | disclosed |
| EP-0143016-B1 | DERIVATIVES OF 4-(3-ALKYNYLOXY-2-HYDROXY-PROPYL)-PIPERAZIN-1-YL-N-PHENYL ACETAMIDE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1987-07-29 | — | — | EP | disclosed |
| EP-0143016-A1 | Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-N-phenyl acetamide, their preparation and their therapeutical use | RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.) (FR) | 1985-05-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | ATG7, BECN1, SQSTM1 | ALDH1A1 4188/4885RAB9A 223/4885HPGD 3815/4885 |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | RNF114, RNF4, RNF168 | ALDH1A1 2969/4885RAB9A 2224/4885HPGD 4624/4885 |
| US-20200054651-A1 | COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A | PPP2R1A, PPP3CA, PPP2R2A | ALDH1A1 2930/4885RAB9A 716/4885HPGD 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.