Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10814023 | 0.78 | MEN1 (0.46) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL10815763 | 0.78 | MEN1 (0.46) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL14348199 | 0.78 | PYGL (0.46) | MAPK1 | |
| SCHEMBL10817102 | 0.78 | MTNR1A (0.44) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL11206777 | 0.75 | ADRB2 (0.45) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL11210336 | 0.75 | MEN1 (0.45) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL11209310 | 0.73 | CYP3A4 (0.43) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL10669378 | 0.71 | MTNR1A (0.40) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL10817817 | 0.71 | MEN1 (0.46) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL11272560 | 0.70 | ALDH1A1 (0.42) | MEN1KMT2ACYP3A4ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091328-B1 | TRANS-4-AMINOBENZ(C,D)INDOL-5-OL DERIVATIVES, THEIR SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-11-11 | — | — | EP | disclosed |
| EP-0091328-A2 | Trans-4-aminobenz(c,d)indol-5-ol derivatives, their salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1983-10-12 | — | — | EP | disclosed |