SCHEMBL10824434

SCHEMBL10824434

CO[Si](Cl)(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA4 P22748 2/20 0.38
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
POLB P06746 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
ALDH1A1 P00352 2/20 0.32
LTA4H P09960 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
MAPT P10636 2/20 0.31
TSHR P16473 4/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
ORAI1 Q96D31 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1224540 0.79 CA4 (0.38) CA4ESR1ESR2POLBCA12
SCHEMBL1224337 0.79 CA4 (0.38) CA4ESR1ESR2POLBCA12
SCHEMBL297042 0.78 TSHR (0.33) ESR1ESR2ALDH1A1LTA4HTSHR
SCHEMBL4195240 0.77 ESR1 (0.38) CA4ESR1ESR2POLBCA12
SCHEMBL18108034 0.75 CA4 (0.35) CA4ESR1ESR2POLBCA12
SCHEMBL18108055 0.75 CA4 (0.35) CA4ESR1ESR2POLBCA12
SCHEMBL8971809 0.75 ESR1 (0.37) ESR1ESR2
SCHEMBL7787435 0.75 ESR1 (0.37) ESR1ESR2
SCHEMBL646249 0.75 CA4 (0.43) CA4ESR1ESR2POLBCA12
SCHEMBL9259574 0.74 ORAI1 (0.31) ESR1ESR2TSHRORAI1ORAI2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61072791-A None JP disclosed
US-11807758-B2 Siloxane polymer and method of producing siloxane polymer JNC CORPORATION (JP) 2023-11-07 US disclosed
CN-113387978-B Method for preparing diphenyl dimethoxysilane by continuous alcoholysis method 江西蓝星星火有机硅有限公司 2022-05-10 CN disclosed
CN-113387978-A Method for preparing diphenyl dimethoxysilane by continuous alcoholysis method 江西蓝星星火有机硅有限公司 2021-09-14 CN disclosed
US-20210238419-A1 SILOXANE POLYMER AND METHOD OF PRODUCING SILOXANE POLYMER JNC CORPORATION (JP) 2021-08-05 US disclosed
US-9884928-B2 Polymers functionalized with activated nitrogen heterocycles containing a pendant functional group BRIDGESTONE CORPORATION (JP) 2018-02-06 US disclosed
US-20160289354-A1 POLYMERS FUNCTIONALIZED WITH ACTIVATED NITROGEN HETEROCYCLES CONTAINING A PENDANT FUNCTIONAL GROUP BRIDGESTONE CORPORATION (JP) 2016-10-06 US disclosed
US-20160009830-A1 SUPPORTED POLYOLEFIN CATALYST AND PREPARATION AND APPLICATION THEREOF PETROCHINA COMPANY LIMITED (CN) 2016-01-14 US disclosed
JP-S6172791-A PRODUCTION OF DIALKOXYDIPHENYLSILANE YUKI GOSEI YAKUHIN KOGYO KK 1986-04-14 JP disclosed