Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Isatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.95 |
| ▸ | MAOB | P27338 | 6/20 | 0.95 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.64 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FER | P16591 | 1/20 | 0.64 |
| ▸ | LTK | P29376 | 1/20 | 0.64 |
| ▸ | CDK8 | P49336 | 1/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | CASP2 | P42575 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.60 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | TGM2 | P21980 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isatin SCHEMBL973760 | 0.98 | MAOA (1.00) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL34016 | 0.98 | MAOA (1.00) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL1590864 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL4092377 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL7061560 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL23256320 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL11646710 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL28365971 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL2259764 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL29370079 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025056913-A1 | COMPOUND AND METHOD | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2025-03-20 | — | — | WO | disclosed |
| US-4593106-A | 4-[2-(dialkylamino)ethyl]-7-hydroxyisatins | SMITHKLINE BECKMAN CORPORATION (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0167288-A2 | 4-(2-(N,N-disubstituted-amino)ethyl]isatins | SMITHKLINE BEECHAM CORPORATION (US) | 1986-01-08 | — | — | EP | disclosed |