Isatin

Isatin

SCHEMBL34016

O=C1Nc2ccccc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 1.00
MAOB P27338 6/20 1.00
LRRK2 Q5S007 3/20 0.67
ACVR1 Q04771 2/20 0.67
PDGFRA P16234 1/20 0.67
FER P16591 1/20 0.67
LTK P29376 1/20 0.67
CDK8 P49336 1/20 0.67
DYRK1B Q9Y463 1/20 0.67
CASP3 P42574 1/20 0.62
CASP2 P42575 1/20 0.62
CASP7 P55210 1/20 0.62
CASP6 P55212 1/20 0.62
CASP8 Q14790 1/20 0.62
CSNK1G1 Q9HCP0 1/20 0.53
GSK3B P49841 1/20 0.52
CES1 P23141 4/20 0.52
TGM2 P21980 3/20 0.52
MAPT P10636 3/20 0.52
MEN1 O00255 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isatin SCHEMBL973760 1.00 MAOA (1.00) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL2259764 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL4092377 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL29370079 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL1590864 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL23256320 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL10833581 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL11646710 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL7061560 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA
Isatin SCHEMBL29869001 0.98 MAOA (0.95) MAOAMAOBLRRK2ACVR1PDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17005 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) WELLA GERMANY GMBH (DE) 2026-05-28 US claimed
CN-118459390-B 3-Hydroxy oxindole derivative containing Z-type 1, 4-dicarbonyl olefin, and preparation method and application thereof SUN YAT-SEN UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122075327-A Scalp itching relieving composition and application thereof 2026-05-26 CN claimed
CN-122091657-A Hyperbranched anion exchange membrane and preparation method thereof 2026-05-26 CN claimed
WO-2026104266-A1 USE OF A NATURAL OCCURRING POLYPHENOL AS AN OXIDATIVE COUPLER DYE PRECURSOR IN AN OXIDATIVE HAIR COLOURING COMPOSITION WELLA GERMANY GMBH (DE) 2026-05-21 WO claimed
CN-122036739-A 3,4' -Pyrano [2,3-c ] pyrazole spiro oxindole derivative, and preparation method and application thereof 遵义医药高等专科学校 2026-05-15 CN claimed
EP-4739272-A1 OXIDATIVE HAIR COLOURING COMPOSITION Wella Germany GmbH (DE) 2026-05-13 EP claimed
CN-122006512-A Ion solvation microporous membrane resistant to high temperature and high concentration alkali, preparation method and application thereof 亳州学院 2026-05-12 CN claimed
US-12622856-B2 Agent for oxidative dyeing of keratin fibers, containing isatin and at least one defined polymer HENKEL AG & CO. KGAA (DE) 2026-05-12 US claimed
US-12617889-B1 Polymers for use as anion exchange membranes ENVISION ENERGY USA LTD. (US) 2026-05-05 US claimed
US-4198516-A Isatin-derived dispersed dyes MONTEDISON S.P.A. (IT) 1980-04-15 US claimed
US-4188325-A Isatin process and products REGENTS OF UNIVERSITY OF MINNESOTA (US) 1980-02-12 US claimed
US-4180405-A COLOR-FORMING LACTONES OR SPIROPYRANS WITH CYCLIC POLYKETO COLOR PRECURSOR GRAPHIC CONTROLS CORPORATION (US) 1979-12-25 US claimed
EP-0003565-A1 Disperse dyes based on isatin derivatives and process for their preparation, and their use for dyeing and printing synthetic fibres Montedison S.p.A. (IT) 1979-08-22 EP claimed
US-4111703-A HEAT-SENSITIVE COATING COMPOSITION WITH 4-AROMATIC AND HYDROXY SUBSTITUTED PIPERIDINE DERIVATIVE AND CYCLIC POLYKETO COMPOUND GRAPHIC CONTROLS CORPORATION (US) 1978-09-05 US claimed
US-4094687-A A DIIMINOPIPERAZINE-ALDEHYDE CONDENSATION PRODUCT AND CYCLIC POLYKETO COMPOUND GRAPHIC CONTROLS CORPORATION 1978-06-13 US claimed
US-4072712-A FROM ISOCYANATES, CATALYSIS BAYER AKTIENGESELLSCHAFT (DT) 1978-02-07 US claimed
US-4061831-A CYCLIC POLYKETO, THIURAM POLYSULFIDE BARD LABORATORIES, INC. (US) 1977-12-06 US claimed
US-3979320-A Liquid crystal composition HODOGAYA CHEMICAL CO., LTD. (JA) 1976-09-07 US claimed
US-RE28789-E ETHYLENICALLY UNSATURATED MONOMER; RADIATION ABSORBER E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-04-27 US claimed