Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.95 |
| ▸ | MAOB | P27338 | 6/20 | 0.95 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.64 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FER | P16591 | 1/20 | 0.64 |
| ▸ | LTK | P29376 | 1/20 | 0.64 |
| ▸ | CDK8 | P49336 | 1/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | CASP2 | P42575 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.60 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | TGM2 | P21980 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isatin SCHEMBL34016 | 0.98 | MAOA (1.00) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL973760 | 0.98 | MAOA (1.00) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL23256320 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL4092377 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL7061560 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL11646710 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL10833581 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL29370079 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL2259764 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL28441354 | 0.95 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150158845-A1 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES | ABBVIE DEUTSCHLAND (DE) | 2015-06-11 | — | — | US | disclosed |
| US-9023854-B2 | 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-05-05 | — | — | US | disclosed |
| CN-102026995-B | 5, 6-disubstituted oxindole derivatives and their use | ABBOTT GMBH & CO.KG (DE) | 2014-10-29 | — | — | CN | disclosed |
| CN-101952276-B | 5-halo substituted oxindole derivatives and their use for the treatment of vasopressin dependent diseases | ABBOTT GMBH & CO.KG (DE) | 2014-10-22 | — | — | CN | disclosed |
| CN-203443897-U | Detection chamber for active particles generated by plasma under pulse discharge | UNIV FUZHOU | 2014-02-19 | — | — | CN | disclosed |
| CN-103439326-A | Detection method and detection chamber for pulse discharge plasma active particles | UNIV FUZHOU | 2013-12-11 | — | — | CN | disclosed |
| US-20110092516-A1 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES | ABBOTT GMBH & CO. KG | 2011-04-21 | — | — | US | disclosed |
| CN-102026995-A | 5, 6-disubstituted oxindole derivatives and their use for the treatment of vasopressin dependent diseases | ABBOTT GMBH & CO KG | 2011-04-20 | — | — | CN | disclosed |
| CN-101952276-A | 5-halo substituted oxindole derivatives and their use for the treatment of vasopressin dependent diseases | ABBOTT GMBH & CO KG | 2011-01-19 | — | — | CN | disclosed |
| CN-101000302-A | Ozone analyzer | CHEN LINXING (CN) | 2007-07-18 | — | — | CN | disclosed |
| CN-1076348-C | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO LTD (US) | 2001-12-19 | — | — | CN | disclosed |
| CN-1144800-A | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO (US) | 1997-03-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092516-A1 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES | AVPR2, AVPR1B, AVPR1A | MAOA 874/4885MAOB 776/4885LRRK2 1215/4885 |
| US-20150158845-A1 | 5-HALOGEN-SUBSTITUTED OXINDOLE DERIVATIVES AND USE THEREOF FOR TREATING VASOPRESSIN-DEPENDENT DISEASES | AVPR2, AVPR1B, AVPR1A | MAOA 874/4885MAOB 776/4885LRRK2 1215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.