Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 1.00 |
| ▸ | MAOB | P27338 | 6/20 | 1.00 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.67 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.67 |
| ▸ | FER | P16591 | 1/20 | 0.67 |
| ▸ | LTK | P29376 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | CASP2 | P42575 | 1/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | CASP6 | P55212 | 1/20 | 0.62 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.62 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | TGM2 | P21980 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isatin SCHEMBL34016 | 1.00 | MAOA (1.00) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL2259764 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL4092377 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL29370079 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL1590864 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL23256320 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL10833581 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL11646710 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL7061560 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA | |
| Isatin SCHEMBL29869001 | 0.98 | MAOA (0.95) | MAOAMAOBLRRK2ACVR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110002877-A1 | PTEN Inhibitors Treat Neutropenia-Associated Pneumonia | CHILDREN'S MEDICAL CENTER CORPORATION | 2011-01-06 | — | — | US | claimed |
| JP-10338693-A | — | — | None | — | — | JP | disclosed |
| WO-2023179922-A1 | AGENT FOR OXIDATIVE DYEING OF KERATIN FIBRES, CONTAINING ISATIN AND AT LEAST ONE DEFINED POLYMER | HENKEL AG & CO. KGAA (DE) | 2023-09-28 | — | — | WO | disclosed |
| CN-108853102-A | Act on the condensed acridine derivatives and application thereof of Dectin-1 | 北京大学 | 2018-11-23 | — | — | CN | disclosed |
| US-8871718-B2 | Transglutaminase inhibitors and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-10-28 | — | — | US | disclosed |
| US-8470782-B2 | Transglutaminase inhibitors and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-06-25 | — | — | US | disclosed |
| US-20130102633-A1 | TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-04-25 | — | — | US | disclosed |
| US-8153593-B2 | Transglutaminase inhibitors and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-04-10 | — | — | US | disclosed |
| CN-102358729-A | 3-hydroxy- indol-2-one derivatives, anti-plant virus disease drugs adopting 3-hydroxy-indol-2-one derivatives as active ingredients, and application thereof | KUNMING INST BOTANY CN ACAD | 2012-02-22 | — | — | CN | disclosed |
| US-20110286995-A1 | Drug Therapy for Celiac Sprue | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2011-11-24 | — | — | US | disclosed |
| US-20080044401-A1 | DRUG THERAPY FOR CELIAC SPRUE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2008-02-21 | — | — | US | disclosed |
| US-20070251025-A1 | Hair coloring kits and methods of use thereof | THE PROCTER & GAMBLE COMPANY | 2007-11-01 | — | — | US | disclosed |
| US-7265093-B2 | Drug therapy for Celiac Sprue | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-09-04 | — | — | US | disclosed |
| WO-2007025247-A2 | TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007010201-A2 | MEDICAL DEVICES AND COATINGS THEREFOR | ASTON UNIVERSITY (GB) | 2007-01-25 | — | — | WO | disclosed |
| EP-1706129-A1 | DRUG THERAPY FOR CELIAC SPRUE | The Board of Trustees of The Leland Stanford Junior University (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20060052308-A1 | Administering to a patient an effective dose of [(S)-1-[(3-Bromo-4,5-dihydro-isoxazol-5-ylmethyl)-methyl-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester; treatment of glioblastoma, meningioma, melanoma and colon cancer | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2006-03-09 | — | — | US | disclosed |
| WO-2005049064-A1 | DRUG THERAPY FOR CELIAC SPRUE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20040167069-A1 | Drug therapy for Celiac Sprue | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-08-26 | — | — | US | disclosed |
| JP-H10338693-A | ISATIN DERIVATIVE | NIPPON ZOKI PHARMACEUT CO LTD | 1998-12-22 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044401-A1 | DRUG THERAPY FOR CELIAC SPRUE | SI, DNPEP, SPINT2 | MAOA 3071/4885MAOB 2372/4885LRRK2 3709/4885 |
| US-20110002877-A1 | PTEN Inhibitors Treat Neutropenia-Associated Pneumonia | CSF3R, CSF1R, ATM | MAOA 4736/4885MAOB 4745/4885LRRK2 677/4885 |
| US-20130102633-A1 | TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF | TGM2, TGM3, TGM1 | MAOA 436/4885MAOB 267/4885LRRK2 3008/4885 |
| US-20110286995-A1 | Drug Therapy for Celiac Sprue | SI, DNPEP, SPINT2 | MAOA 3071/4885MAOB 2372/4885LRRK2 3709/4885 |
| US-20060052308-A1 | Administering to a patient an effective dose of [(S)-1-[(3-Bromo-4,5-dihydro-isoxazol-5-ylmethyl)-methyl-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester; treatment of glioblastoma, meningioma, melanoma and colon cancer | MGMT, GMFG, HNMT | MAOA 599/4885MAOB 473/4885LRRK2 3819/4885 |
| US-20040167069-A1 | Drug therapy for Celiac Sprue | SI, DNPEP, SPINT2 | MAOA 3071/4885MAOB 2372/4885LRRK2 3709/4885 |
| US-20070251025-A1 | Hair coloring kits and methods of use thereof | COXFA4L2, SQOR, GPX4 | MAOA 192/4885MAOB 193/4885LRRK2 4751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.