Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.57 |
| ▸ | RARB | P10826 | 8/20 | 0.57 |
| ▸ | RARG | P13631 | 7/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10834790 | 0.88 | RARA (0.55) | RARARARBRARGPPARGCYP3A4 | |
| SCHEMBL8102850 | 0.87 | RXRA (0.55) | RARARARBRARGPPARGCYP3A4 | |
| SCHEMBL21451484 | 0.84 | CYP11B1 (0.59) | CYP11B1CYP11B2 | |
| SCHEMBL10835419 | 0.83 | RXRA (0.41) | RARARARBRARGCYP11B1CYP11B2 | |
| SCHEMBL10834477 | 0.80 | RARB (0.59) | RARARARBRARGPPARGCYP26A1 | |
| SCHEMBL18775432 | 0.78 | RARB (0.73) | RARARARBRARGCYP11B1CYP11B2 | |
| SCHEMBL12058771 | 0.78 | PTPN11 (0.47) | RARARARBRARGCYP11B1CYP11B2 | |
| SCHEMBL21620954 | 0.78 | ALDH1A1 (0.61) | CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL10835377 | 0.77 | RARA (0.60) | RARARARBRARGCYP26A1RXRA | |
| SCHEMBL29567307 | 0.76 | CYP26A1 (0.74) | RARBRARGPPARGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4581380-A | TREATMENT OF SKIN DISORDERS;ANTIINFLAMMATORY AGENTS | Groupement Economique dite: Centre National de Recherches Dermatologiques C.I.R.D. (FR) | 1986-04-08 | — | — | US | disclosed |