Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL229544 | 1.00 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL107290 | 1.00 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28324410 | 0.98 | TSHR (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7801203 | 0.96 | TSHR (0.36) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL67551 | 0.93 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27537584 | 0.93 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL67549 | 0.93 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL231340 | 0.93 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Vinyl Chloride SCHEMBL7527788 | 0.92 | HCAR2 (0.42) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7949814 | 0.91 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4576866-A | VINYL ACETATE-VINYL CHLORIDE COPOLYMER | FUJI PHOTO FILM CO., LTD. (JP) | 1986-03-18 | — | — | US | disclosed |