Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL107290 | 0.96 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL229544 | 0.96 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL10836232 | 0.96 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28324410 | 0.94 | TSHR (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL9306995 | 0.94 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Vinyl Chloride SCHEMBL8967461 | 0.93 | HCAR2 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Acrylic Acid SCHEMBL9452202 | 0.90 | LMNA (0.42) | ALDH1A1 | |
| Vinyl Chloride SCHEMBL7576429 | 0.89 | ALDH1A1 (0.35) | TSHRALDH1A1HSD17B10TDP1 | |
| Vinyl Chloride SCHEMBL338690 | 0.89 | ALDH1A1 (0.35) | TSHRALDH1A1HSD17B10TDP1 | |
| Maleic Acid SCHEMBL67549 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4539257-A | FERROMAGNETIC AND CARBON BLACK PARTICLES IN BINDER | FUJI PHOTO FILM CO., LTD. (JP) | 1985-09-03 | — | — | US | claimed |
| EP-0747071-B1 | Lubricious coatings containing polymers with vinyl and carboxylic acid moieties | UNION CARBIDE CHEM PLASTIC (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5731087-A | HYDROPHILIC AND BINDER POLYMERS; MEDICAL EQUIPMENT | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1998-03-24 | — | — | US | disclosed |
| US-5620738-A | COATING SUBSTRATE SURFACE WITH HYDROPHILIC POLYMER AND BINDER COPOLYMER OF VINYL CHLORIDE, VINYL ACETATE AND A CARBOXYLIC ACID | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0747071-A1 | Lubricious coatings containing polymers with vinyl and carboxylic aced moieties | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5176955-A | Running durability | FUJI PHOTO FILM CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5156908-A | Lower magnetic layer containing acicular ferromagnetic powder, upper containing plate shaped ferromagnetic alloy powder with different properties | FUJI PHOTO FILM CO., LTD. (JP) | 1992-10-20 | — | — | US | disclosed |
| US-5139866-A | Video, audio and magnetic tapes with excellent running durability and stability | FUJI PHOTO FILM CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-5062904-A | Treatment of ferromagnetic metal powders and magnetic recording media using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| US-4983311-A | BINDER IS VINYL CHLORIDE COPOLYMER CONTAINING HYDROXYL GROUP CONTAINING UNSATURATED ETHER | NIPPON ZEON CO., LTD. (JP) | 1991-01-08 | — | — | US | disclosed |
| US-4539257-A | FERROMAGNETIC AND CARBON BLACK PARTICLES IN BINDER | FUJI PHOTO FILM CO., LTD. (JP) | 1985-09-03 | — | — | US | disclosed |