Fumaric Acid

Fumaric Acid

SCHEMBL229544

C=CCl.C=COC(C)=O.O=C(O)C=CC(=O)O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.39
TP53 P04637 1/20 0.39
EGLN1 Q9GZT9 1/20 0.39
EGLN3 Q9H6Z9 1/20 0.39
HCAR2 Q8TDS4 5/20 0.38
ALDH1A1 P00352 6/20 0.34
ALOX15 P16050 2/20 0.34
RECQL P46063 2/20 0.34
HSD17B10 Q99714 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
LMNA P02545 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL107290 1.00 TSHR (0.39) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL10836232 1.00 TSHR (0.39) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL28324410 0.98 TSHR (0.38) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL7801203 0.96 TSHR (0.36) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL67551 0.93 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL27537584 0.93 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL67549 0.93 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL231340 0.93 TSHR (0.45) TSHRTP53EGLN1EGLN3HCAR2
Vinyl Chloride SCHEMBL7527788 0.92 HCAR2 (0.42) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL7949814 0.91 TSHR (0.43) TSHRTP53EGLN1EGLN3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 497 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111574786-A Preparation method and use method of low-temperature plasticized orthopedic gloves 安徽攀望科技有限公司 2020-08-25 CN claimed
US-20180194128-A1 ENHANCED MASK FOR REDUCING LIGHT SCATTERING ULANO INTERNATIONAL 2018-07-12 US claimed
CN-108251023-A A kind of effective adhering resin of lined with PVC steel plastic compount and its preparation method and application 上海邦中高分子材料有限公司 2018-07-06 CN claimed
CN-104710586-B A kind of polystyrene polyacrylic acid ester polyurethane unsaturated polyester (UP) copolymer and preparation method thereof 深圳市格莱特印刷材料有限公司 2017-12-15 CN claimed
CN-104114450-B The manufacture method of paper-made vessel and this paper-made vessel DIXIE JAPAN LTD. (JP) 2016-01-13 CN claimed
CN-104710890-A Peelable protective ink and preparation method thereof SHENZHEN GLITER PRINTING MATERIALS & EQUIPMENT CO LTD 2015-06-17 CN claimed
CN-104710586-A Polystyrene-polyacrylate-polyurethane-unsaturated polyester copolymer and preparation method thereof SHENZHEN GLITER PRINTING MATERIALS & EQUIPMENT CO LTD 2015-06-17 CN claimed
CN-104114450-A Paper container and manufacturing method thereof DIXIE JAPAN CO LTD 2014-10-22 CN claimed
CN-1973017-B Cross-linked encapsulated phosphorescent molecules KIMBERLY CLARK CO 2012-11-21 CN claimed
US-7662528-B2 Charge generating composition XEROX CORPORATION (US) 2010-02-16 US claimed
EP-0189868-B1 PACKAGING MATERIAL AND SEALING CAP NIPPON FILM INDUSTRIAL CO., LTD. (JP) 1991-03-13 EP claimed
US-4745014-A Packaging material and sealing cap NIPPON FILM INDUSTRIAL CO., LTD. (JP) 1988-05-17 US claimed
US-4731278-A FERROMAGNETIC PARTICLES CONTAIN COBALT FUJI PHOTO FILM CO., LTD. (JP) 1988-03-15 US claimed
US-4619855-A FERROMAGNETIC FINES IN POLYMER BLEND OF VINYL ACETATE (OR PROPIONATE)-VINYL CHLORIDE COPOLYMER, POLYURETHANE AND ACRYLIC RESIN FUJI PHOTO FILM CO., LTD. (JP) 1986-10-28 US claimed
EP-0189868-A2 Packaging material and sealing cap NIPPON FILM INDUSTRIAL CO., LTD. (JP) 1986-08-06 EP claimed
US-4576866-A VINYL ACETATE-VINYL CHLORIDE COPOLYMER FUJI PHOTO FILM CO., LTD. (JP) 1986-03-18 US claimed
US-4560616-A VINYL-TYPE COPOLYMER, URETHANE RESIN AND AN ACRYLOYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1985-12-24 US claimed
US-4557856-A Electrically conductive composition for electro-responsive recording materials MITA INDUSTRIAL CO., LTD. (JP) 1985-12-10 US claimed
US-4539257-A FERROMAGNETIC AND CARBON BLACK PARTICLES IN BINDER FUJI PHOTO FILM CO., LTD. (JP) 1985-09-03 US claimed
US-4283474-A ELECTOGRAPHY KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-08-11 US claimed