Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL67551 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27537584 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL67549 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28215238 | 0.98 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28185469 | 0.98 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7949814 | 0.98 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL9306995 | 0.95 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL5175869 | 0.95 | LMNA (0.46) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4981541 | 0.95 | LMNA (0.46) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL10836232 | 0.93 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1387 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113512451-A | Lubricating oil composition for internal combustion engine and preparation method thereof | 中国石油化工股份有限公司 | 2021-10-19 | — | — | CN | claimed |
| CN-106350217-B | A kind of preparation method of low cloud point fatty acid type diesel antiwear additive | 中海油天津化工研究设计院有限公司 | 2019-05-28 | — | — | CN | claimed |
| EP-3320062-A1 | USES AND COMPOSITIONS | Castrol Limited (GB) | 2018-05-16 | — | — | EP | claimed |
| CN-106350217-A | Preparation method of low-cloud-point fatty acid type diesel antiwear additive | 中海油天津化工研究设计院有限公司 | 2017-01-25 | — | — | CN | claimed |
| WO-2017005865-A1 | USES AND COMPOSITIONS | CASTROL LIMITED (GB) | 2017-01-12 | — | — | WO | claimed |
| US-8980803-B2 | Lubricant base stocks with improved filterability | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2015-03-17 | — | — | US | claimed |
| US-20140274845-A1 | LUBRICANT BASE STOCKS WITH IMPROVED FILTERABILITY | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2014-09-18 | — | — | US | claimed |
| WO-2014143510-A1 | LUBRICANT BASE STOCKS WITH IMPROVED FILTERABILITY | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2014-09-18 | — | — | WO | claimed |
| US-20090307964-A1 | USE OF SOLUBILIZERS FOR HOMOGENIZING ADDITIVE CONCENTRATES | BASF SE (DE) | 2009-12-17 | — | — | US | claimed |
| WO-2009150145-A1 | USE OF SOLUBILIZERS FOR HOMOGENIZING ADDITIVE CONCENTRATES | BASF SE (DE) | 2009-12-17 | — | — | WO | claimed |
| EP-1259581-A4 | REDUCING LOW TEMPERATURE SCANNING BROOKFIELD GEL INDEX VALUE IN ENGINE OILS | EXXON RESEARCH ENGINEERING CO (US) | 2003-03-26 | — | — | EP | claimed |
| EP-1259581-A1 | REDUCING LOW TEMPERATURE SCANNING BROOKFIELD GEL INDEX VALUE IN ENGINE OILS | Exxon Research and Engineering Company (US) | 2002-11-27 | — | — | EP | claimed |
| WO-2001021741-A1 | REDUCING LOW TEMPERATURE SCANNING BROOKFIELD GEL INDEX VALUE IN ENGINE OILS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 2001-03-29 | — | — | WO | claimed |
| US-6136760-A | LUBRICANT COMPOSITION CONTAINING BOTH A DIALKYL FUMARATE-VINYL ACETATE LOW TEMPERATURE FLOW IMPROVER AND SORBITAN FATTY ACID ESTER OR A POLYOXYALKYLENE SORBITAN FATTY ACID ESTER HAS REDUCED GEL INDEX | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 2000-10-24 | — | — | US | claimed |
| US-5743923-A | FUEL OIL COMPRISING MIXTURE OF VEGETABLE OIL, PETROLEUM BASED MIDDLE DISTILLATE FRACTION, TWO DIFFERENT ETHYLENE-VINYL ACETATE COPOLYMERS; NONSETTLING | EXXON CHEMICAL PATENTS INC. (US) | 1998-04-28 | — | — | US | claimed |
| EP-0777713-A1 | IMPROVED LUBRICATING OIL COMPOSITIONS | EXXON CHEMICAL PATENTS INC. (US) | 1997-06-11 | — | — | EP | claimed |
| WO-1996005276-A1 | IMPROVED LUBRICATING OIL COMPOSITIONS | EXXON CHEMICAL PATENTS INC. (US) | 1996-02-22 | — | — | WO | claimed |
| CN-1081692-A | Oil dope and composition thereof | EXXON CHEMICAL PATENTS INC (US) | 1994-02-09 | — | — | CN | claimed |
| EP-0277007-B1 | CRUDE OIL AND FUEL OIL COMPOSITIONS | EXXON CHEMICAL PATENTS INC. (US) | 1992-09-23 | — | — | EP | claimed |
| US-4460453-A | Solvent dewaxing waxy bright stock using a combination polydialkyl fumarate-vinyl acetate copolymer and polyalkyl (meth-) acrylate polymer dewaxing aid | EXXON RESEARCH AND ENGINEERING CO. (US) | 1984-07-17 | — | — | US | claimed |