Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10836349 | 1.00 | PKM (0.41) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL10836355 | 1.00 | PKM (0.41) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL10964113 | 0.91 | MMP8 (0.38) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL10964108 | 0.91 | MMP8 (0.38) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL335584 | 0.85 | PKM (0.43) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL3737736 | 0.78 | MMP8 (0.41) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL11136882 | 0.76 | MMP8 (0.40) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL13287418 | 0.75 | MMP8 (0.39) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL2438993 | 0.75 | MMP8 (0.39) | PKMMMP8KDM4EALDH1A1LMNA | |
| SCHEMBL29220128 | 0.75 | MMP8 (0.43) | PKMMMP8KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567195-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING, AKTIENGESELLSCHAFT (DE) | 1986-01-28 | — | — | US | disclosed |
| EP-0059756-B1 | 7-OXOPROSTACYCLIN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-08-28 | — | — | EP | disclosed |
| US-4532236-A | Certain prostacyclins and their blood-pressure-lowering and thrombocyte-aggregation-inhibiting compositions and methods | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| US-4466969-A | 7-Oxoprostacyclin derivatives and their use as hypotensives and bronchodilators | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-08-21 | — | — | US | disclosed |
| US-4446147-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0059756-A1 | 7-OXOPROSTACYCLIN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF. | SCHERING AG (DE) | 1982-09-15 | — | — | EP | disclosed |
| WO-1982001002-A1 | 7-OXOPROSTACYCLIN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | NICKOLSON R | 1982-04-01 | — | — | WO | disclosed |