Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737736 | 0.92 | MMP8 (0.41) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL11136882 | 0.91 | MMP8 (0.40) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL2438993 | 0.89 | MMP8 (0.39) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL13287418 | 0.89 | MMP8 (0.39) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL10836337 | 0.85 | PKM (0.41) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL10836349 | 0.85 | PKM (0.41) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL10836355 | 0.85 | PKM (0.41) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL10655712 | 0.84 | CYP4F2 (0.46) | PKMMMP8ALDH1A1LMNAHSD17B10 | |
| SCHEMBL3743133 | 0.80 | MEN1 (0.45) | PKMMMP8KDM4ETHRBHTT | |
| SCHEMBL14815133 | 0.79 | ALOX15 (0.47) | ALDH1A1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3461816-B1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-24 | — | — | EP | disclosed |
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3461816-A1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-12-28 | — | — | US | disclosed |
| US-9840471-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2015-12-31 | — | — | US | disclosed |
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| US-8222404-B2 | [1,2,4]Thiadiazin-3-yl acetic acid compound and methods of making the acetic acid compound | ANADYS PHARMACEUTICALS, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-20090306057-A1 | [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| US-20090306057-A1 | [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| US-20090306057-A1 | [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| US-4567195-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING, AKTIENGESELLSCHAFT (DE) | 1986-01-28 | — | — | US | disclosed |
| EP-0094951-B1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4532236-A | Certain prostacyclins and their blood-pressure-lowering and thrombocyte-aggregation-inhibiting compositions and methods | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| US-4446147-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0058632-B1 | (13E)-(8R,11R,12R)-11,15-DIHYDROXY-16,19-DIMETHYL-9-OXO-13,18-PROSTADIENOIC ACIDS AND THEIR SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-04-11 | — | — | EP | disclosed |
| EP-0094951-A1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF. | SCHERING AG (DE) | 1983-11-30 | — | — | EP | disclosed |
| WO-1983001951-A1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF | NICKOLSON, ROBERT | 1983-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | PKM 1435/4885MMP8 1909/4885ALDH1A1 1692/4885 |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | PKM 1435/4885MMP8 1909/4885ALDH1A1 1692/4885 |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | PKM 1435/4885MMP8 1909/4885ALDH1A1 1692/4885 |
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | PKM 1435/4885MMP8 1909/4885ALDH1A1 1692/4885 |
| US-20090306057-A1 | [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS | CYP2E1, CYP1A1, CYP1B1 | PKM 4434/4885MMP8 4268/4885ALDH1A1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.