Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10838026 | 0.99 | DRD2 (0.59) | DRD2HTR1AKCNH2HTR1DHTR1B | |
| SCHEMBL10570148 | 0.82 | DRD2 (0.59) | DRD2HTR1ASLC6A4SIGMAR1HTR7 | |
| SCHEMBL10837771 | 0.82 | SIGMAR1 (0.52) | DRD2HTR1AKCNH2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL10569016 | 0.81 | DRD2 (0.58) | DRD2HTR1ASLC6A4SIGMAR1HTR7 | |
| Hydrochloric Acid SCHEMBL10569951 | 0.81 | DRD2 (0.58) | DRD2HTR1ASLC6A4SIGMAR1HTR7 | |
| SCHEMBL10570868 | 0.79 | DRD2 (0.56) | DRD2HTR1ASLC6A4SIGMAR1HTR7 | |
| SCHEMBL10570129 | 0.79 | DRD2 (0.55) | DRD2HTR1AHTR7 | |
| SCHEMBL10835787 | 0.78 | HTR1A (0.48) | DRD2HTR1AHTR7 | |
| SCHEMBL10838127 | 0.77 | DRD2 (0.68) | DRD2HTR1ASLC6A4SIGMAR1HTR7 | |
| SCHEMBL10836380 | 0.77 | DRD2 (0.46) | DRD2HTR1AKCNH2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |