Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838043 | 0.89 | SCN1A (0.47) | DRD2SCN1ASCN5ASCN9AALDH1A1 | |
| SCHEMBL10836233 | 0.86 | HTR1A (0.56) | HTR1AHTR7DRD2SCN1ASCN5A | |
| SCHEMBL10836259 | 0.86 | HTR1A (0.53) | HTR1AHTR7DRD2SCN1ASCN5A | |
| SCHEMBL10836177 | 0.85 | S1PR1 (0.44) | HTR1ADRD2DRD4DRD3 | |
| Water SCHEMBL10836253 | 0.85 | S1PR1 (0.43) | HTR1ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10837925 | 0.85 | S1PR1 (0.43) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL11290166 | 0.85 | HTR1A (0.52) | HTR1AHTR7DRD2DRD4DRD3 | |
| SCHEMBL10836422 | 0.83 | HTR1A (0.46) | HTR1AHTR7DRD2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10837514 | 0.82 | DRD2 (0.51) | HTR1ADRD2SCN1ASCN5ASCN9A | |
| SCHEMBL10838437 | 0.81 | DRD2 (0.55) | HTR1AHTR7DRD2SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |