Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.40 |
| ▸ | PPARD | Q03181 | 14/20 | 0.40 |
| ▸ | PPARA | Q07869 | 14/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642927 | 0.73 | GPBAR1 (0.36) | GAA | |
| SCHEMBL10663367 | 0.63 | PPARG (0.56) | PPARGPPARDPPARA | |
| SCHEMBL10658435 | 0.63 | PPARG (0.53) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL9828053 | 0.63 | ALOX15 (0.45) | PPARGPPARDPPARAMEN1GAA | |
| SCHEMBL9827198 | 0.63 | POLB (0.41) | PPARGPPARDPPARAMEN1GAA | |
| SCHEMBL10643636 | 0.62 | GPBAR1 (0.34) | PPARGPPARDPPARACYP1A2 | |
| SCHEMBL4013334 | 0.62 | PPARA (0.54) | PPARGPPARDPPARA | |
| SCHEMBL9827847 | 0.61 | PPARG (0.42) | PPARGPPARDPPARA | |
| SCHEMBL27495332 | 0.61 | ALDH1A1 (0.59) | MEN1GAAKMT2A | |
| SCHEMBL14010211 | 0.60 | PPARA (0.52) | PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602028-A | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-07-22 | — | — | US | disclosed |