Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842854 | 0.78 | CASP1 (0.40) | SMN1; SMN2KDM4EGAACYP1A2ACHE | |
| SCHEMBL10843076 | 0.78 | CYP11B2 (0.46) | SMN1; SMN2KDM4EGAACYP1A2ACHE | |
| SCHEMBL10844756 | 0.78 | CYP1A2 (0.42) | SMN1; SMN2GAACYP1A2MEN1KMT2A | |
| SCHEMBL11240500 | 0.75 | KDM4E (0.39) | SMN1; SMN2KDM4ECYP1A2CHUKALDH1A1 | |
| SCHEMBL10843959 | 0.75 | CYP1A2 (0.35) | SMN1; SMN2KDM4EGAACYP1A2MEN1 | |
| SCHEMBL10841297 | 0.74 | ALDH1A1 (0.45) | SMN1; SMN2KDM4ECYP1A2ACHEMEN1 | |
| SCHEMBL10843843 | 0.70 | ALDH1A1 (0.38) | SMN1; SMN2KDM4EGAACYP1A2ALDH1A1 | |
| SCHEMBL10843051 | 0.70 | CASP1 (0.39) | — | |
| SCHEMBL10844104 | 0.64 | CCNC (0.46) | KDM4ECYP1A2ALDH1A1HPGDLMNA | |
| SCHEMBL12691782 | 0.64 | ACHE (0.58) | SMN1; SMN2KDM4EGAACYP1A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590194-A | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use | STERLING DRUG INC. (US) | 1986-05-20 | — | — | US | disclosed |