Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.41 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 known ✓ | P04626 | 1/20 | 0.39 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.39 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL10844789 | 1.00 | HCAR2 (0.50) | HCAR2SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| Maleic Acid SCHEMBL10843397 | 0.88 | LMNA (0.48) | HCAR2SLC6A2SLC6A4SLC6A3HTR2B | |
| Fumaric Acid SCHEMBL10843401 | 0.88 | LMNA (0.48) | HCAR2SLC6A2SLC6A4SLC6A3HTR2B | |
| Fumaric Acid SCHEMBL10844039 | 0.88 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3EGFRERBB2 | |
| Maleic Acid SCHEMBL10844025 | 0.88 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3EGFRERBB2 | |
| Maleic Acid SCHEMBL10845393 | 0.87 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL10845402 | 0.87 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3 | |
| Maleic Acid SCHEMBL10844166 | 0.87 | HRH1 (0.41) | SLC6A2SLC6A4SLC6A3HTR2BADRB2 | |
| Fumaric Acid SCHEMBL10844175 | 0.87 | HRH1 (0.41) | SLC6A2SLC6A4SLC6A3HTR2BADRB2 | |
| Maleic Acid SCHEMBL10845356 | 0.86 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3ALDH1A1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4605654-A | ANTIDEPRESSANTS; ANALGESICS | P. F. MEDICAMENT (FR) | 1986-08-12 | — | — | US | disclosed |