Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12909408 | 0.81 | HRH1 (0.72) | HRH1HRH4DRD3DRD2CHRM2 | |
| SCHEMBL10846692 | 0.81 | SETD7 (0.54) | HRH1DRD3DRD2CHRM2ADRA2A | |
| SCHEMBL10962757 | 0.80 | SETD7 (0.55) | HRH1DRD3DRD2CHRM2ADRA2A | |
| Etolotifen SCHEMBL2109044 | 0.79 | DRD3 (0.68) | HRH1HRH4DRD3DRD2CHRM2 | |
| Etolotifen SCHEMBL10851254 | 0.78 | DRD3 (0.67) | HRH1HRH4DRD3DRD2CHRM2 | |
| SCHEMBL10848598 | 0.77 | DRD3 (0.52) | HRH1HRH4DRD3DRD2CHRM2 | |
| SCHEMBL10848583 | 0.77 | DRD3 (0.52) | HRH1HRH4DRD3DRD2CHRM2 | |
| SCHEMBL10962040 | 0.74 | CHRM2 (0.57) | HRH1DRD3DRD2CHRM2ADRA2A | |
| SCHEMBL24172560 | 0.74 | HRH1 (0.53) | HRH1HRH4DRD3DRD2CHRM2 | |
| SCHEMBL12909407 | 0.73 | HRH1 (1.00) | HRH1HRH4DRD3DRD2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4609664-A | ANTIALLERGIC | SANDOZ LTD. (CH) | 1986-09-02 | — | — | US | disclosed |
| EP-0047226-A2 | Piperidylidene derivatives, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1982-03-10 | — | — | EP | disclosed |