Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12909408 | 0.84 | HRH1 (0.72) | HRH1HRH4LMNAHTTHTR2C | |
| SCHEMBL3042815 | 0.75 | HRH1 (0.68) | HRH1HRH4LMNAJAK2HTT | |
| Bromide SCHEMBL11602086 | 0.74 | HRH1 (0.66) | HRH1HRH4LMNAJAK2HTT | |
| SCHEMBL10846771 | 0.73 | HRH1 (0.57) | HRH1HRH4LMNAHTR2CCHRM2 | |
| SCHEMBL6178102 | 0.72 | SETD7 (0.58) | HRH1HRH4LMNAJAK2HTT | |
| SCHEMBL31350956 | 0.72 | SETD7 (0.58) | HRH1HRH4LMNAJAK2HTT | |
| SCHEMBL20381726 | 0.71 | HRH1 (0.54) | HRH1HRH4LMNAHTR2CCHRM2 | |
| SCHEMBL20978905 | 0.71 | HRH1 (0.54) | HRH1HRH4LMNAHTR2CCHRM2 | |
| SCHEMBL20381716 | 0.71 | HRH1 (0.54) | HRH1HRH4LMNAHTR2CCHRM2 | |
| Hydrochloric Acid SCHEMBL5729405 | 0.71 | LMNA (0.84) | HRH1HRH4LMNAJAK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727919-B1 | BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO LTD (CN) | 2019-05-08 | — | — | EP | disclosed |
| US-10022362-B2 | Anti-allergy benzocycloheptathiophene derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD (CN) | 2018-07-17 | — | — | US | disclosed |
| US-7872025-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872025-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7557128-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557128-B2 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20090149502-A1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | ABERG A K GUNNAR | 2009-06-11 | — | — | US | disclosed |
| US-20090149502-A1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | ABERG A K GUNNAR | 2009-06-11 | — | — | US | disclosed |
| US-20080287498-A1 | Having antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of ketotifen | ABERG A K GUNNAR | 2008-11-20 | — | — | US | disclosed |
| US-20080287498-A1 | Having antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of ketotifen | ABERG A K GUNNAR | 2008-11-20 | — | — | US | disclosed |
| US-7226934-B1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-7226934-B1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | BRIDGE PHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287498-A1 | Having antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of ketotifen | OPRK1, HRH2, HRH1 | HRH1 3/4885HRH4 10/4885LMNA 4194/4885 |
| US-20090149502-A1 | Optically active isomers of ketotifen and therapeutically active metabolites thereof | OPRK1, HRH1, HRH2 | HRH1 2/4885HRH4 7/4885LMNA 4200/4885 |
| US-10022362-B2 | Anti-allergy benzocycloheptathiophene derivatives | NR1H4, TST, CYP7A1 | HRH1 14/4885HRH4 11/4885LMNA 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.