Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.48 |
| ▸ | DRD1 | P21728 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848598 | 1.00 | DRD3 (0.52) | DRD3DRD2HRH1LMNACHRM2 | |
| Etolotifen SCHEMBL2109044 | 0.87 | DRD3 (0.68) | DRD3DRD2HRH1LMNACHRM2 | |
| Etolotifen SCHEMBL10851254 | 0.86 | DRD3 (0.67) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL11306556 | 0.82 | DRD3 (0.69) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL11306554 | 0.82 | DRD3 (0.69) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL10846692 | 0.80 | SETD7 (0.54) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL10962757 | 0.78 | SETD7 (0.55) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL10846771 | 0.77 | HRH1 (0.57) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL10962040 | 0.73 | CHRM2 (0.57) | DRD3DRD2HRH1LMNACHRM2 | |
| SCHEMBL10961042 | 0.72 | ADRA2A (0.58) | DRD3DRD2HRH1LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4609664-A | ANTIALLERGIC | SANDOZ LTD. (CH) | 1986-09-02 | — | — | US | disclosed |
| EP-0047226-B1 | PIPERIDYLIDENE DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1985-05-15 | — | — | EP | disclosed |